Against Advanced Glycation End-products

Searching, Utilizing, and Conserving of Tropical Forest Derived Drugs Ameliorating Degenerative Disorders

in collaboration with: Muhammad Zahid
Penguji di Balai Besar Pengujian Mutu dan Sertifikasi Obat Hewan dan Peneliti di University of New South Wales, Australia.

Abstract
Advanced glycation end-products (PAGP) emerge as a relatively new research discipline, giving its importance in inducing degenerative disorders namely aging, diabetes, renal failure, and Alzheimer. This group of vast chemical substances is natively produced in-vivo or can also be obtained from foods. Less information and research of PAGP observed in Indonesia in recent day. Hence, this article is aimed to give a new horizon of the significance of PAGP in our health. On the other hand, Indonesian rain forests are a house of potential plant extracts that can cure and ease PAGP-induced diseases. This review would also elaborate potentially curative and preventive substances from Indonesian rain forest plant extracts. Efficacy against PAGP-induced diseases has been observed from forest plants, namely mushroom (Ganoderma spp.), tea leaf (Camellia sinensis and Ilex paraguariensis), red guava leaf (Psidium guava), stem of tea parasite (Loranthus parasiticus), and sambiloto (Andrographis paniculata). The idea of utilizing and conserving PAGP drug plants consists of four main concepts (1) ethno-botanic and pharmacognosy research; (2) extraction and method developments; (3) commercialization and protection of natural resources; as well as (4) cultivation and conservation of forest-based medicines. Jargon of Indonesia as a massive house for world flora should also be followed by implementation of forest-based drug utilization.

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